Metoprolol Base is the free-base form of Metoprolol, a selective beta-1 blocker used to treat hypertension, angina, and related cardiovascular conditions. Kodel Life manufactures it under ISO 9001:2015 controls, suitable for global API formulations with documented process validation and batch traceability.
Every batch of Metoprolol Succinate or Metoprolol Tartrate starts from the same free base. Which acid it meets next, succinic or tartaric, decides which finished beta-blocker salt reaches the pharmacy shelf.
At Kodel Life, we produce Metoprolol Base in IP, BP, USP, and EP grades with a monthly output of 62 MT, our highest single-intermediate capacity. Our manufacturing plant operates under ISO 9001:2015 certification and supplies to pharmaceutical companies in 21 countries across 5 continents.
This page covers everything a pharma buyer, formulator, or procurement head needs to know before choosing a Metoprolol Base supplier.
What Is Metoprolol Base?
Chemical Profile & Synonyms
Metoprolol Base is the non-salt, free-base form of metoprolol. Manufacturers convert it into Metoprolol Succinate or Metoprolol Tartrate by reacting it with the corresponding acid, succinic acid or tartaric acid, in a salt-formation step.
Parameter
Value
Generic Name
Metoprolol Base
CAS Number
37350-58-6
Molecular Formula
C15H25NO3
Molecular Weight
267.36 g/mol
Also Known As
(RS)-Metoprolol, CGP 2175, Metoprolol free base
Application
Betablocker intermediate
Pharmacopoeial Grades
IP, BP, USP, EP
Physical Form
White to off-white crystalline solid
How a Single Base Becomes Two Different Beta-Blocker Salts
Metoprolol Base does not reach patients in its free-base form. It is always converted to a salt first, and the acid used at that step determines which finished API results.
In practice, this means Metoprolol Base is the point at which a single feedstock can branch into either finished beta-blocker salt, depending on which acid the downstream manufacturer chooses. A common situation is a buyer needing to lock in supply ahead of a seasonal demand increase; because this is a high-capacity line, Kodel Life can generally accommodate larger forecast volumes with more scheduling flexibility than lower-capacity intermediates.
Where This Intermediate Sits in the Synthesis Route
A quick map of how Metoprolol Base moves from raw feedstock to finished therapy, so you can confirm this is the stage you actually need before ordering.
Starting Materials
Metoprolol Base (this intermediate)
Metoprolol Succinate API
Salt formed with succinic acid
Metoprolol Tartrate API
Salt formed with tartaric acid
Hypertension, angina & heart failure therapy
Why Demand for Metoprolol Intermediates Keeps Growing
Metoprolol has been a first-line beta-blocker for decades, and demand tracks the same forces driving global cardiovascular drug consumption.
According to WHO estimates, approximately 1.28 billion adults aged 30–79 years live with hypertension worldwide
Rising incidence of heart failure and post-myocardial-infarction management protocols that call for beta-blocker therapy
Increasing use of generic Metoprolol formulations in emerging markets
Expansion of hospital-based cardiac care in Africa, Southeast Asia, and South America
India manufactures over 20% of the world's generic APIs and intermediates by volume. Several of the largest Metoprolol intermediate manufacturers operate out of Gujarat and Maharashtra, benefiting from established chemical supply chains and skilled pharma workforces.
Metoprolol Base Technical Specifications
Grades Available: IP, BP, USP, EP
Procurement teams sourcing Metoprolol Base for regulated markets need the right pharmacopoeial grade. Here is what each covers:
IP
Indian Pharmacopoeia
Required for products marketed in India and several South Asian and African markets.
BP
British Pharmacopoeia
Accepted across the UK, the Commonwealth, and many EU countries.
USP
United States Pharmacopeia
Mandatory for products entering the US market and many Latin American regulators.
EP
European Pharmacopoeia
Required for EU market access; often accepted alongside BP.
Kodel Life supplies all four grades from a single manufacturing facility, which reduces sourcing complexity for exporters managing multi-market compliance.
Pharmacopoeial Standards & Purity
Every batch of Metoprolol Base we release undergoes testing per pharmacopoeial specifications, including:
Assay (HPLC) against the applicable pharmacopoeial limit
Related substances and impurity profiling
Residual solvents (ICH Q3C Class 2 and 3)
Heavy metals and elemental impurities (ICH Q3D)
Particle size distribution
Water content by Karl Fischer titration
Certificate of Analysis (COA), technical specifications, and regulatory documentation support are available upon request. Documentation availability may vary depending on the destination market and regulatory requirements.
Packaging, Storage & Handling
Packaging
Double-lined HDPE drums with moisture-proof inner lining, typical of Kodel Life's other bulk intermediates. Exact pack size is confirmed at quotation.
Storage
Cool, dry place away from direct light. Recommended temperature below 25°C.
Shelf Life
Confirmed on the Certificate of Analysis for each batch; consistent with the storage conditions above.
Transport classification and export documentation, including COA and MSDS, are confirmed with each shipment.
Why Buyers Choose Kodel Life for Metoprolol Base
Pharmaceutical companies sourcing this intermediate need more than competitive pricing. They need consistent quality, reliable documentation, and dependable supply continuity.
Manufacturing capacity of 62 MT per month, our highest-volume intermediate
Available in IP, BP, USP, and EP grades
ISO 9001:2015 certified quality management system
Batch-specific Certificate of Analysis (COA)
Export supply experience across multiple international markets
Technical support for formulation and procurement teams
Consistent batch-to-batch quality control procedures
Documentation support available for qualified buyers
Why Source Metoprolol Base from India?
India accounts for a significant share of global intermediate and API exports, and the reasons are structural rather than coincidental.
Regulatory Infrastructure
India has the second-highest number of US FDA-approved manufacturing sites outside the US.
Cost Advantage
Labor, raw material, and utility costs in India remain significantly lower than in Europe or North America without compromising output quality.
Scale
Large Indian manufacturers can handle multi-tonne monthly orders with consistent batch-to-batch quality.
Speed to Market
Established logistics corridors from JNPT, Mundra, and Chennai ports reduce lead times for global buyers.
Documentation Readiness
Leading intermediate and API manufacturers often maintain regulatory documentation such as DMFs, ASMFs, CEPs, or market-specific dossiers depending on their target export markets.
For buyers in the US, EU, Southeast Asia, or Africa sourcing an intermediate supplier for export, India-based manufacturers offer the most practical combination of price, scale, and compliance.
Where Metoprolol Base Is Used Downstream
This intermediate feeds more than one finished API, depending on the acid or synthesis step a manufacturer applies next.
Metoprolol Succinate API
Reacting Metoprolol Base with succinic acid produces Metoprolol Succinate, used in extended-release tablets for once-daily hypertension, angina, and heart failure therapy.
Metoprolol Tartrate API
Reacting the same base with tartaric acid produces Metoprolol Tartrate, the immediate-release salt used for acute dosing and titration in cardiovascular treatment.
Explore Related Manufacturing Capabilities
In addition to this intermediate, Kodel Life supports pharmaceutical companies through a broad range of manufacturing and documentation services.
API Manufacturing Services
Intermediates Supply at Scale
Quality Control & Testing
Export Documentation Support
Pharmaceutical Contract Manufacturing
Comparing Metoprolol Base Suppliers: What Actually Matters
Not every intermediate supplier will fit every buyer's situation. Here is a practical comparison of the key variables:
Factor
What to Check
Why It Matters
Certifications
ISO 9001, FDA compliance, EDQM CEP
Determines which regulated markets you can sell into
Documentation Availability
COA with every batch; DMF/CEP reference where applicable
Needed if your own API filing references this intermediate
Production Capacity
MT per month, surge capacity
Avoids supply disruptions during peak demand
Grades Offered
IP / BP / USP / EP
Must match your target market's pharmacopoeial requirements
Lead Time
Standard and expedited timelines
Affects planning cycles and inventory management
Synonym Accuracy
CAS number matched to every trade name used
Prevents ordering the wrong impurity or intermediate by mistake
Export Track Record
Countries served, logistics partners
Reduces risk of first-shipment compliance issues
Kodel Life checks every box in this table. We have been exporting to 21 countries and maintain active documentation for all four pharmacopoeial grades.
What to Look for When Choosing a Metoprolol Base Manufacturer
Certifications: ISO, FDA, EDQM
A certificate is only as good as the audit trail behind it. When evaluating any intermediate manufacturer, ask specifically for:
ISO 9001:2015 scope certificate covering this specific intermediate line
FDA establishment registration number (verifiable on FDA.gov)
EDQM CEP (Certificate of Suitability) if you target European markets
Kodel Life holds ISO 9001:2015 certification and follows documented quality management systems designed to support pharmaceutical intermediate manufacturing. Product documentation, including COA and technical specifications, is available to qualified buyers upon request.
COA & Documentation Availability
A Drug Master File (DMF) is a submission to a regulatory authority (USFDA, EMA, PMDA) that contains confidential details about the manufacturing process, facilities, and controls behind a drug substance or key intermediate. Buyers planning US or EU market launches should confirm whether their supplier's documentation can be referenced in a New Drug Application or Abbreviated New Drug Application.
At Kodel Life, COA and DMF-linked documentation is available upon request for qualified buyers. Our team supports the technical transfer process from the first enquiry.
Production Capacity & Lead Times
62 MT/Month
Metoprolol Base production capacity
62 MT/Month
Total capacity across all products
2–4 Weeks
Standard lead time for stocked material
Custom batch orders take 6 to 8 weeks depending on specifications.
Common Mistakes Pharma Buyers Make When Sourcing Metoprolol Base
1
Treating the base as interchangeable with either salt
Metoprolol Base itself is not Metoprolol Succinate or Tartrate. Confirm which salt-formation step your own process performs before ordering the base instead of a finished salt.
2
Not confirming the grade before ordering
An IP-grade intermediate cannot support a US ANDA filing. Always map the grade to your regulatory target market before placing an order.
3
Underestimating lead time at peak season
Because this is a high-volume line, buyers who wait until the last month of forecasted demand risk queueing behind other bulk orders. Lock in volume early.
4
Skipping supplier audits
Even for small initial orders, request a supplier self-audit questionnaire or arrange a remote audit for the intermediate line specifically.
5
Not asking for DMF or CEP reference letters upfront
If your API filing needs to reference this intermediate's manufacturing route, clarify documentation support before placing the first order.
Get Metoprolol Base Samples & Pricing
If you are sourcing Metoprolol Base in bulk for formulation, further synthesis, or export, our team can walk you through grade options, documentation packages, and dispatch timelines. Whether you need one tonne or twenty, the process starts the same way: a conversation with our technical sales team.
Samples
Available for pre-qualified buyers
COA / DMF
Available upon formal inquiry
62 MT/Month
Metoprolol Base capacity
21 Countries
USA, UK, EU, Africa, SEA
Reach out through the enquiry form or contact us directly. We respond within 1 to 2 business days.
Interested in This Product?
Contact our team to discuss pricing, availability, and custom requirements.
Quality Certifications
ISO 9001:2015
Quality Management System
FDA Compliant
Regulatory Compliance
Why Buyers Choose Kodel Life
Manufacturing capacity of 62 MT per month, our highest-volume intermediate
Available in IP, BP, USP, and EP grades
ISO 9001:2015 certified quality management system
Batch-specific Certificate of Analysis (COA)
Export supply experience across multiple international markets
Technical support for formulation and procurement teams
Consistent batch-to-batch quality control procedures
Metoprolol Base is the free-base form of the beta-blocker metoprolol, CAS 37350-58-6, used as the primary raw material to manufacture Metoprolol Succinate and Metoprolol Tartrate.
No. Metoprolol Base is the neutral, non-salt form of the molecule. Manufacturers react it with tartaric acid to produce Metoprolol Tartrate, or with succinic acid to produce Metoprolol Succinate.
The CAS number is 37350-58-6.
Kodel Life supplies Metoprolol Base at IP, BP, USP, and EP grade, to match different regulatory markets.
62 MT per month currently, Kodel Life's highest-volume intermediate.
Yes. Every batch ships with a Certificate of Analysis, and Drug Master File access is available on request for qualified buyers.
Yes. Kodel Life provides samples to pre-qualified buyers for evaluation. Submit your enquiry through the contact page or the form on this page and specify your target grade and quantity.
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